New Drug Comes Closer to Eliminating Type 2 Diabetes
Although hereditary, type 2 diabetes is mainly thought to be brought about by a poor diet and being overweight over a long period of time.
So far, there’s been no medical treatment for insulin resistance, but a new drug forged by researchers at the University of California cancelled out the condition by effectively “curing” type 2 diabetes in mice.
A report showed giving the drug to mice with insulin resistance every day had positive results. An enzyme called low molecular weight protein tyrosine phosphate, or LMPTP, which is found in the liver, inactivates the insulin receptor.
The drug was designed to inhibit LMPTP. By inhibiting the enzyme in the liver, insulin receptor effectiveness was restored.
“Our findings suggest that LMPTP is a key promoter of insulin resistance and that LMPTP inhibitors would be beneficial for treating type 2 diabetes,” the team said in their study published in Nature.
The drug was orally administered to lab mice who were fed a high-fat diet. The mice developed obesity and type 2 diabetes because of the diet. The drug had no side-effects on the rats, and their blood sugar levels fell to normal levels for a while.
The researcher will have to work for another two years to get approval to start a human clinical trial.
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